Developing tests to assess the brain chemical system
Lewy body dementia (LBD), which includes Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is a condition that results in problems in a brain chemical system called the cholinergic system, which contributes to symptoms like visual hallucinations, risk of falls, problems with walking and our ability to think, speak, read and understand (cognition) the world around us.
In this study, we aim to study how several non-invasive tests including an electroencephalography (brain wave test), transcranial magnetic stimulation, MRI brain scan, gait test and body activity sensors can detect dysfunction of the brain cholinergic system and the response to cholinergic enhancing drugs.
We are looking for healthy volunteers to assess these tests in people without Lewy body dementia as a comparison.
This study is funded by the NIHR Newcastle Biomedical Research Centre.
The research team are looking for healthy volunteers (people without Lewy body dementia) aged 60 and over to take part.
What will I be asked to do?
Taking part in this study would involve a two-hour home visit for an interview and a single visit to Newcastle University to undergo the afore-mentioned tests. The total test time is approximately 3 hours and will be spaced out over one-full day during office hours with rest in-between. At the end of the visit you will be asked to wear a small activity monitor around your waist for the next week. You will be given an envelope to return the monitor after one week.
When and where?
Appointments will be arranged for a convenient time between you and the research team.
The visit will be to the Clinical Ageing Research Unit, Newcastle University, NE4 5PL.
Will I get anything for taking part?
Travel expenses will be reimbursed and lunch will be provided on the day of the visit.
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