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This is an opportunity to take part in a study looking at the effects of nitrate on cognitive function and cerebral blood flow in older adults.
The date given above is not the date of the study, appointments will be arranged between the participant and the researcher.
Several human studies have showed that dietary nitrate supplementation was associated with a significant reduction of blood pressure, improved exercise performance and brain flow. Preliminary animal and human investigations have reported an improvement of cognitive function (memory and executive performance) after dietary nitrate supplementation, which appears to be explained by an improved blood flow and more efficient metabolism of the cells.
As we age, our cognitive function declines and the risk of impairment in cognitive function increases. Therefore, it is vital to research into older adults.
No study to the researcher's knowledge have investigated the long term effect of different doses of nitrate on cognitive function and cerebral blood flow in older overweight participants and this study aims to fill this research gap.
The aim of this study is to investigate the effect of different doses of nitrate rich beetroot juice on cognitive function and cerebral blood flow, and other health and wellbeing parameters during a 13 week nutritional intervention study.
Cognitive performance will be tested using computerised cognitive tasks. In addition, vascular and lung function will be tested beside other health biomarkers such as glucose, oxidative stress and inflamation.
To take part you must:
To find out your body mass index, please click here.
Some medications and conditions that interfere with the study outcomes will be excluded. These include (but not restricted) antacids, epilepsy and psyschoactive medications.
This is a nutritional intervention study in which participants will be asked to consume either nitrate rich beetroot juice or nitrate depleted beetroot juice for a 13 week period. Some participants will be asked to consume beetroot juice daily, while others will be asked to consume it every other day.
Participants will be asked to continue their normal diet throughout, making the supplementation the only change. Beetroot juice for the study will be all provided.
The study involve 6 visits, 4 visits will be at research facility in Newcastle University and 2 visits will be at Brain performance and nutrition research facility at Northumbria University.
Visit 1: This is screening visit which involve assessment of eligibility using BMI, blood pressure and participants will be trained on the cognitive tasks (around 2 hours, at Newcastle Uni research facility)
Visit 2: This is first study visit, and participants will be asked to be fast for at least 8 hours before the visit. Baseline testing involves measurement of body composition, vascular and pulmonary function and series of cognitive tasks. Participants will be asked to provide blood, urine and saliva samples beside using salivary strip (a tool help measure nitrite in saliva). Several saliva samples will be provided to collect several saliva samples at home. Participants will also be asked to complete a number of questionnaires. (around 3 hours,at Newcastle Uni research facility)
Visit 3: Next day, continue baseline measurement. In this visit we will measure the cerebral blood flow. Only saliva and urine samples will be required in addition to use salivary strip (No blood sample) (around 1 hour, at Northumbria Uni research facility).
Visit 4: will be 6 weeks after visit 3. Blood pressure and body composition will be measured. Participants will be asked to complete the same cognitive tasks.
Visit 5: Will be 6 weeks after visit 4. Testing will follow same format as second visit.
Visit 6: Next day, testing will follow same format as third visit.
The study will be running for 1 year so appointments will be arranged between the participant and the researcher.
The study will take place at Newcastle University Food Research Facility and the Brain performance and nutrition facility at Northumbria University.
You will receive a £60 voucher for taking part and reasonable travel expenses can be reimbursed.