A new way to assess the impact of normal ageing on bones, joints and muscles has been proposed that could provide a benchmark for how well older people are able to keep moving.
The composition of the body changes as we get older, as muscle strength and bone density decline. But the challenge to date has been distinguishing between the normal effects of ageing and the first signs of disease.
As a result there has been limited consensus on appropriate biomarkers of normal ageing. This has led to an unreliable picture of musculoskeletal health in older people as bone, joints and muscle have been looked at in isolation, not as a complete system.
To address this, experts at the Medical Research Council-Arthritis UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) – a collaboration between Newcastle, Liverpool and Sheffield universities – have now proposed a set of measurements that can be used as a toolkit to assess bone, joint and muscle health.
Publishing in the journal Age and Ageing, the CIMA team say that the new toolkit will provide a consistent and holistic way to measure the gradual loss of function that everyone experiences as we get older.
In particular, they recommend the use of two biomarkers to assess bone condition – PINP and CTX, both well-established indicators of bone turnover. High levels of these biomarkers are often associated with greater fracture risk and faster rates of bone loss, particularly in older women.
The toolkit also proposes reliable indicators of cartilage damage, muscle mass, body composition and assessment of functional capability.
Professor John Mathers, from Newcastle University’s Institute for Ageing, said: “We know that when older people have limited mobility or stop being active altogether it can have a significant, negative impact on their cardio-vascular health, their neurological health and their quality of life overall, increasing the risk of disease.
“This new toolkit will help us better understand how well the whole musculoskeletal system functions as we age so that we can help people stay physically active and healthy for longer.”
To read the full article please visit the Newcastle University website.